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These include starting with a very low dose, ensuring the highest purity of the compound, using proper sterile techniques, and maintaining good hydration and baseline health in the research subject

While heterogeneity and limited study numbers warrant caution, these results highlight GLP-1RAs as promising candidates for AUD management

Martinelli, S

We thank the Imperial College Facility for Imaging by Light Microscopy (FILM) for technical support on light microscopy experiments, the Electron Microscopy Centre at the Centre of Structural Biology, Imperial College London, for support during TEM data acquisition, and Dr Ricardo Aramayo at the Electron Microscopy Facility of the MRC Laboratory of Medical Sciences (LMS) for support during cryo-CLEM sample preparation

Those with a BMI of 27 kg/m and weight-related health issues could be eligible

In the SURMOUNT-1 trial, tirzepatide at the highest dose (15 mg) produced average weight loss of 22.5% versus approximately 15% for semaglutide in comparable trials